%0 Journal Article
%T No Correlation between <i>AVPR</i>1A Promoter Polymorphisms and Prepulse Inhibition  in Patients with Nocturnal Enuresis
%A Sebastian Schulz-Juergensen
%A Philipp von Bismarck
%A Ren¨¦ Santer
%A Paul Eggert
%J Open Journal of Nephrology
%P 20-27
%@ 2164-2869
%D 2014
%I Scientific Research Publishing
%R 10.4236/ojneph.2014.41004
%X <p style=\"text-align:justify;\">
	<i><span style=\"font-size:10pt;line-height:1.5;font-family:Verdana;\">Introduction</span></i><span style=\"font-size:10.0pt;line-height:102%;font-family:;\" \"=\"\"><span style=\"font-family:Verdana;line-height:1.5;\">: A correlation between </span><i><span style=\"font-family:Verdana;line-height:1.5;\">AVPR</span></i><span style=\"font-family:Verdana;line-height:1.5;\">1</span><i><span style=\"font-family:Verdana;line-height:1.5;\">A</span></i><span style=\"font-family:Verdana;line-height:1.5;\"> promoter
polymorphisms and prepulse inhibition (PPI) of startle reflexes has been
described in healthy adults. Many children with nocturnal enuresis (NE) have a
reduced PPI and treatment with desamino arginine vasopressin (dDAVP), a ligand
of the arginine vasopressin receptor 1A (AVPR1A), </span></span><span style=\"font-size:10pt;line-height:1.5;font-family:Verdana;\">and </span><span style=\"font-size:10.0pt;line-height:102%;font-family:;\" \"=\"\"><span style=\"font-family:Verdana;line-height:1.5;\">both improve clanical symptoms and significantly
increase PPI. </span><i><span style=\"font-family:Verdana;line-height:1.5;\">Methods</span></i><span style=\"font-family:Verdana;line-height:1.5;\">: In 17 children
(median 9.1 years, range 6.4-17.3) with NE, promoter repeats within the RS1
and RS3 regions of </span><i><span style=\"font-family:Verdana;line-height:1.5;\">AVPR</span></i><span style=\"font-family:Verdana;line-height:1.5;\">1</span><i><span style=\"font-family:Verdana;line-height:1.5;\">A</span></i><span style=\"font-family:Verdana;line-height:1.5;\"> were quantified and correlated to PPI
(native and age-adjusted). </span><i><span style=\"font-family:Verdana;line-height:1.5;\">Results</span></i><span style=\"font-family:Verdana;line-height:1.5;\">: No
direct correlation was found between the number of promo</span></span><span style=\"font-size:10pt;line-height:1.5;font-family:Verdana;\">ter repeats at RS1 and PPI (correla</span><span style=\"font-size:10pt;line-height:1.5;font-family:Verdana;\">tion coefficient</span><span style=\"font-size:10pt;line-height:1.5;font-family:Verdana;\">¡ª</span><span style=\"font-size:10pt;line-height:1.5;font-family:Verdana;\">0.2</span><span style=\"font-size:10pt;line-height:1.5;font-family:Verdana;\">40, p = 0.346) or RS3 and PPI (correlation
coefficient</span><span style=\"font-size:10pt;line-height:1.5;font-family:Verdana;\">¡ª</span><span style=\"font-size:10.0pt;line-height:102%;font-family:;\" \"=\"\"><span style=\"font-family:Verdana;line-height:1.5;\">0.0192, p = 0.936),
%K &lt
%K i&gt
%K AVPR&lt
%K /i&gt
%K 1A Promoter
%K Prepulse Inhibition
%K Nocturnal Enuresis
%K Correlation
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=44087