%0 Journal Article
%T Synthesis, Resolution and Absolute Configuration of 2,3-Dihydro-2-<i>Tert</i>-Butyl-3-<i>N</i>-Benzylquinazolin-4-One: A Possible Chiral Auxiliary for Synthesis of <i>¦Â</i>-Amino Cyclohexancarboxylic Acid
%A Fanny A. Cabrera-Rivera
%A Jaime Escalante
%J International Journal of Organic Chemistry
%P 48-54
%@ 2161-4695
%D 2014
%I Scientific Research Publishing
%R 10.4236/ijoc.2014.41007
%X 3-Benzyl-2-(<i>tert</i>-butyl)-2,3-dihydroquinazolin-4(1<i>H</i>)-one <i>rac</i>-11 was resolved via the preparation of diastereomers with <i>N</i>-phthalyl-<i>L</i>-alanine chloride and its absolute configuration was determined by X-ray crystallographic analysis. This heterocycle has potential as a substrate chiral in asymmetric induction due to the steric effects of its <i>tert</i>-butyl group.
%K Chiral Auxiliary
%K 2-Tert-Butyl-Quinazolin-4-One
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=43829