%0 Journal Article
%T Synthesis and Physicochemical Characterization of Biodegradable Star-Shaped Poly Lactide-Co-Glycolide-<i>¦Â</i>-Cyclodextrin Copolymer Nanoparticles Containing Albumin
%A Soodabeh Davaran
%A Akbar Rezaei
%A Somayeh Alimohammadi
%A Amir Ahmad Khandaghi
%A Kazem Nejati-Koshki
%A Hamid Tayefi Nasrabadi
%A Abolfazl Akbarzadeh
%J Advances in Nanoparticles
%P 14-22
%@ 2169-0529
%D 2014
%I Scientific Research Publishing
%R 10.4236/anp.2014.31003
%X <p align=\"justify\">
	<b><span style=\"font-family:Verdana;\">The purposes of this research were to synthesize and characterize star-shaped poly lactide-co-glycolide</span></b><b><span style=\"font-family:Verdana;\">-</span><i><span style=\"font-family:Verdana;\">¦Â</span></i><span style=\"font-family:Verdana;\">-cyclo</span></b><b><span style=\"font-family:Verdana;\">-</span><span style=\"font-family:Verdana;\">dextrin (PLGA</span></b><b><span style=\"font-family:Verdana;\">-</span><i><span style=\"font-family:Verdana;\">¦Â</span></i><span><span style=\"font-family:Verdana;\">-CD) copolymer by reacting L-lactide, glycolide and </span><i><span style=\"font-family:Verdana;\">¦Â</span></i><span style=\"font-family:Verdana;\">-cyclodextrin in the presence of stannous octoate as a catalyst. The structure of PLGA</span></span></b><b><span style=\"font-family:Verdana;\">-</span><i><span style=\"font-family:Verdana;\">¦Â</span></i><span style=\"font-family:Verdana;\">-CD copolymer was confirmed with 1H-NMR, 13C-NMR and FT-IR spectra. Albumin as a model peptide drug was encapsulated within nanoparticles made of PLGA</span></b><b><span style=\"font-family:Verdana;\">-</span><i><span style=\"font-family:Verdana;\">¦Â</span></i><span style=\"font-family:Verdana;\">-CD with a modified double emulsion method. Transmission electron microscopy (TEM) and scanning electron microscopy (SEM) photomicrographs showed that the nanoparticles have the mean diameter within the range of 80 -</span></b><b><span> </span><span style=\"font-family:Verdana;\">210 nm. Also they were almost spherical in shape. Effects of the experimental parameters, such as copolymer composition, copolymer concentration,</span></b><b><span style=\"font-family:Verdana;\"> and</span><span style=\"font-family:Verdana;\"> reaction temperature, on particular size and encapsulation efficiency were investigated.</span></b> 
</p>
<p>
	<span></span> 
</p>
%K Albumin
%K Star-Shaped Poly Lactide-Co-Glycolide
%K &lt
%K i&gt
%K ¦Â&lt
%K /i&gt
%K -Cyclodextrin
%K Nanoparticles
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=42720