%0 Journal Article
%T The effect of melatonin in functional heartburn: A randomized, placebo-controlled clinical trial
%A Patrick P. Basu
%A Hemanth Hempole
%A Nitya Krishnaswamy
%A Niraj J. Shah
%A Mark M. Aloysius
%J Open Journal of Gastroenterology
%P 56-61
%@ 2163-9469
%D 2014
%I Scientific Research Publishing
%R 10.4236/ojgas.2014.42010
%X <span style=\"font-size:10.0pt;font-family:;\" \"=\"\">Background:
Melatonin is a safe and effective treatment for patients with functional pain
and gastrointestinal disorders. Objective: To evaluate the efficacy and
safety of melatonin for 3 months in patients with functional heartburn.
Methods: In the randomized, placebo-controlled pilot study, patients with
functional heartburn were treated with omeprazole 20 mg <span>before breakfast and randomized to receive either
me</span>latonin 6 mg (<i>n </i>= 20),
nortripty line 25 mg (<i>n </i>= 20), or
placebo (<i>n </i>= 20) at bedtime for 3
months. Gastroeso<span>phageal Reflux Disease-Health-Related
Quality of Life (GERD-HRQOL) scores were assessed at baseline and</span> at the
end of the study. Results: Melatonin improved GERD-HRQOL scores compared with
nortriptyline (<i>P </i>= 0.0015) and
placebo (<i>P </i>&lt; 0.0001). Fewer
adverse events were reported by patients receiving melatonin compared with
those receiving nortriptyline or placebo. Conclusions: Melatonin was a safe
and effective treatment for functional heartburn.</span>
%K Melatonin
%K Functional Heartburn
%K Nortriptyline
%K HRQOL
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=42681