%0 Journal Article
%T Effect of Slice Thickness Reconstruction on Quantitative Vascular Parameters in Perfusion CT
%A Anxo Mart¨ªnez-de-Alegr¨ªa
%A Roberto Garc¨ªa-Figueiras
%A Sandra Baleato-Gonz¨¢lez
%A Mar¨ªa Jos¨¦ Rodriguez-Alvarez
%A Iago Mart¨ªnez-Souto
%A Carmen Villalba-Mart¨ªn
%J Open Journal of Radiology
%P 53-59
%@ 2164-3032
%D 2014
%I Scientific Research Publishing
%R 10.4236/ojrad.2014.41007
%X <p style=\"text-align:justify;\">
	Objective: The purpose of this study was to determine
how the slice thickness reconstruction influences quantitative perfusion CT
parameters. Materials and Methods: Eighteen patients with cancer (15 non-small-cell
lung cancer, 2 rectal cancer and 1 renal cancer) were examined prospectively
with multidetector row CT. A 90-second perfusion study was performed after
intravenous bolus injection of contrast material. Blood flow, blood volume,
mean transit time and permeability-surface area product were determined at
three different slice thickness reconstruction (1.25, 2.5 and 5 mms) both in
tumors and in paraspinal muscle. Mean values, limits of agreement between
measurements and within-subject coefficient of correlation were obtained for
these thicknesses. Results: Mean ¡À standard deviation BF, BV, MTT and PS in
lesions were 118.7 ¡À 117.9 mL/min/100g tissue, 8.2 ¡À 8.2 mL/100g tissue, 7.5 ¡À
5.4 seconds and 10.3 ¡À 7.2 mL/min/100g tissue respectively at1.25 mmslice thickness;
116.1 ¡À 115.7 mL/min/100g tissue, 7.8 ¡À 8.7 mL/100g tissue, 7 ¡À 4.5 seconds and
10.4 ¡À 7.5 mL/min/100g tissue at 2.5 mms; and 119.6 ¡À 115.7 mL/min/100g tissue,
7.8 ¡À 8.8 mL/100g tissue, 5.4 ¡À 3.4 seconds and 9.6 ¡À 7.5 mL/min/100g tissue at
5 mms. Differences between means for different slice thickness where relatively
small in all parameters (&lt;15%) except in MTT where difference was up to 37%.
95% limits of agreement were worse when comparing more different slice
thicknesses (e.g. 1.25 vs 5 mms) than when comparing more close slice
thicknesses (1.25 vs 2.5 mms or 2.5 vs 5 mms). Conclusions: There is a
significant variability in perfusion parameter measurements at different slice
thickness reconstruction, particularly in MTT. The more close together the
slice thicknesses were, the smaller was the variability.
</p>
%K Tomography
%K Neoplasms
%K Blood Supply
%K Diagnostic Imaging
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=43039