%0 Journal Article
%T PGE<sub>2</sub> Generation in Myocardium from Isolated Rat Atrium under Hypoxia and Reoxygenation Conditions. Effect of Anti-<i>¦Â</i><sub>1</sub> IgG from Patients with Chronic Severe Periodontitis
%A Sabrina Ganzinelli
%A Silvia Reina
%A Mirian Matoso
%A Germ¨¢n Gonz¨¢lez
%A Celina Morales
%A Enri Borda
%J Pharmacology & Pharmacy
%P 204-215
%@ 2157-9431
%D 2014
%I Scientific Research Publishing
%R 10.4236/pp.2014.52027
%X <p>
	<i><span style=\"font-family:Verdana;\">Background</span></i><span><span style=\"font-family:Verdana;\">: Hypoxia is one
of the most frequently encountered stresses in health and disease. </span><i><span style=\"font-family:Verdana;\">Methods</span></i><span style=\"font-family:Verdana;\">: We compared the effects of an
anti-</span><i><span style=\"font-family:Verdana;\">¦Â</span></i><sub><span style=\"font-family:Verdana;\">1</span></sub><span style=\"font-family:Verdana;\"> periodontal IgG
(pIgG) and an authentic </span><i><span style=\"font-family:Verdana;\">¦Â</span></i><sub><span style=\"font-family:Verdana;\">1</span></sub><span style=\"font-family:Verdana;\"> adrenergic agonist, xamoterol, on isolated myocardium from rat atria
contractility. </span></span><span><span style=\"font-family:Verdana;\">We used an ELISA
assay to measure the generation of PGE</span><sub><span style=\"font-family:Verdana;\">2</span></sub> <i><span style=\"font-family:Verdana;\">in vitro</span></i><span style=\"font-family:Verdana;\"> after the addition of either the antibody or the
adrenergic agonist. We analyzed the myocardium histopathologically in the
presence of both the antibody and/or the adrenergic agonist drug during normoxia,
hypoxia and reperfusion conditions. </span><i><span style=\"font-family:Verdana;\">Results</span></i><span style=\"font-family:Verdana;\">:
PGE</span><sub><span style=\"font-family:Verdana;\">2</span></sub><span style=\"font-family:Verdana;\"> generation increased during the hypoxia and was unchanged
during reoxygenation period compared with the production of this prostanoid in
atria during normoxia condition. A </span><i><span style=\"font-family:Verdana;\">¦Â</span></i><sub><span style=\"font-family:Verdana;\">1</span></sub><span style=\"font-family:Verdana;\"> specific adrenoceptor antagonist atenolol and the </span><i><span style=\"font-family:Verdana;\">¦Â</span></i><sub><span style=\"font-family:Verdana;\">1</span></sub><span style=\"font-family:Verdana;\"> synthetic peptide abrogated the increment of the
prostanoid in the presence of pIgG but only atenolol due </span></span><span style=\"font-family:Verdana;\">to </span><span><span style=\"font-family:Verdana;\">it in the
presence of xamoterol. The increment of PGE</span><sub><span style=\"font-family:Verdana;\">2</span></sub><span style=\"font-family:Verdana;\"> was dependent on the
activatio</span></span><span><span style=\"font-family:Verdana;\">n of </span><i><span style=\"font-family:Verdana;\">cox</span></i><span style=\"font-family:Verdana;\">-1 and </span><i><span
%K Myocardium
%K PGE&lt
%K sub&gt
%K 2&lt
%K /sub&gt
%K Hypoxia
%K Histopathology
%K Periodontitis
%K Antibodies Anti-&lt
%K i&gt
%K ¦Â&lt
%K /i&gt
%K &lt
%K sub&gt
%K 1&lt
%K /sub&gt
%K Adrenoceptors
%K Xamoterol
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=43000