%0 Journal Article
%T Mitochondrial DNA-HVR1 Variation Reveals Genetic Heterogeneity in Thai-Isan Peoples from the Lower Region of Northeastern Thailand
%A Wibhu Kutanan
%A Suparat Srithawong
%A Artittaya Kamlao
%A Jatupol Kampuansai
%J Advances in Anthropology
%P 7-12
%@ 2163-9361
%D 2014
%I Scientific Research Publishing
%R 10.4236/aa.2014.41002
%X <p class=\"MsoNormal\" style=\"text-align:justify;\">
	<span lang=\"EN-GB\"><span style=\"font-family:Verdana;\">The
Thai-Isan are the largest ethnic group in Northeastern Thailand, who migrated
from the territory of present-day Laos around 200 years ago. There are a
limited number of previous studies of mtDNA diversity in Northeastern Thai
populations. The present study investigates genetic variation and genetic
structure in three Thai-Isan populations by analyzing mitochondrial DNA
variation in hypervariable region 1. We also evaluate genetic relationship and
admixture between Thai-Isan and surrounding populations from Northeastern Thailand,
and neighboring countries. The studied Thai-Isan populations reveal genetic
differentiation from each other and from compared populations. Thai-Isan
exhibit a close relationship with surrounding populations, particularly the Lao
and Khmer, reflecting extensive gene flow among them. Admixture proportions
observed in most Thai-Isan populations exhibit a higher contribution from the
parental Lao than the Khmer. Different admixture patterns reflect genetic
heterogeneity of Thai-Isan groups.</span><b> </b><span style=\"font-family:Verdana;\">The lower the latitude, the higher
the Khmer contribution</span><b> </b><span style=\"font-family:Verdana;\">might be associated with the ethnic constitution
of parental populations in each Thai-Isan population.</span><b> </b><span style=\"font-family:Verdana;\">More genetic data
from HVR2 and coding regions, as well as different marker systems are needed to
infer population history of Thai-Isan populations.</span></span>
</p>
%K mtDNA Diversity
%K Genetic Relationship
%K Genetic Admixture
%K Thai-Isan
%K Northeastern Thailand
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=42555