%0 Journal Article
%T Isolation and Spasmolytic Evaluation of New Alkaloids from <i>Dichrostachys cinerea</i> (L.) Wight et Arn. (Fabaceae)
%A Amenan Genevi¨¨ve N¡¯guessan-Iri¨¦
%A Jo£¿l Dade
%A Pierre Champy
%A N¡¯doua Gis¨¨le Siransy-Kouakou
%A V¨¦ronique Leblais
%J Pharmacology & Pharmacy
%P 684-688
%@ 2157-9431
%D 2013
%I Scientific Research Publishing
%R 10.4236/pp.2013.49095
%X <p class=\"MsoNormal\" style=\"text-align:justify;\">
	<i><span lang=\"EN-US\" style=\"font-family:Verdana;\">Dichrostachys</span></i><span lang=\"EN-US\"> <i><span style=\"font-family:Verdana;\">cinerea</span></i><span style=\"font-family:Verdana;\"> (L.) Wight et Arn. (Fabaceae) root
bark is used in Ivorian Traditional Medicine to treat asthma, </span></span><span lang=\"EN-US\" style=\"font-family:Verdana;\">which is </span><span lang=\"EN-US\"><span style=\"font-family:Verdana;\">a respiratory disorder characterized by
inflammation and the restriction of tracheal muscles obstructing the air circulation.
The tracheal relaxant effect of a crude aqueous-alcoholic extract of the plant root
bark was previously shown. For the present study, alkaloids were isolated from the
same extract and investigated </span><i><span style=\"font-family:Verdana;\">ex</span></i> <i><span style=\"font-family:Verdana;\">vivo</span></i><span style=\"font-family:Verdana;\"> in C57Bl/6j mice isolated trachea contracted
with carbachol 1 ¦ÌM, in comparison with a reference bronchodilatator, </span><i><span style=\"font-family:Verdana;\">i.e</span></i><span style=\"font-family:Verdana;\">. salbutamol. Two extraction procedures
allowed isolating 2 Alkaloids </span></span><span lang=\"EN-US\" style=\"font-family:Verdana;\">that</span><span lang=\"EN-US\"><span style=\"font-family:Verdana;\"> monodimensional and bi-dimensional nuclear magnetic resonance (NMR) and mass
specters allowed identifying a pyrolidine structure type nucleus with a long bi-hydroxyled
alkyl chain. Alkaloid 1, carrier of a sugar, is a glycoside of Alkaloid 2. Both
alkaloids induced similar spasmolytic effects, but Alkaloid 1</span><b> </b><span style=\"font-family:Verdana;\">was</span><b> </b><span style=\"font-family:Verdana;\">more effective than</span><b> </b><span style=\"font-family:Verdana;\">Alkaloid
2</span><b> </b><span style=\"font-family:Verdana;\">at</span><b> </b><span style=\"font-family:Verdana;\">9</span></span><span lang=\"EN-US\"> </span><span lang=\"EN-US\" style=\"font-family:Verdana;\">¡Á</span><span lang=\"EN-US\"> </span><span lang=\"EN-US\"><span style=\"font-family:Verdana;\">10<sup>-</sup></span><sup><span style=\"font-family:Verdana;\">6</span></sup><span style=\"font-family:Verdana;\"> M (</span><i><span style=\"font-family:Verdana;\">p</span></i></span><i><span lang=\"EN-US\"> <span style=\"white-space:nowrap;\">£¼</span></span></i><span lang=\"EN-US\"> </span><span lang=\"EN-US\" style=\"font-family:Verdana;\">0.01), 3</span><span lang=\"EN-US\"> </span><span lang=\"EN-US\"
%K Alkaloids Isolated
%K Plant
%K Spasmolytic
%K Asthma
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=40937