%0 Journal Article
%T Short Term Prognostic Utility of Tc-99m DMSA Renal Imaging in Sepsis Induced Acute Renal Failure; Provisional Data
%A Amr Amin
%A Hatem Nasr
%A Gehan Younis
%A Hatem Gamal
%J International Journal of Clinical Medicine
%P 543-547
%@ 2158-2882
%D 2013
%I Scientific Research Publishing
%R 10.4236/ijcm.2013.412094
%X <p class=\"MsoNormal\">
	<span lang=\"EN-US\" style=\"font-family:Verdana;\">Background:</span><span lang=\"EN-US\" style=\"font-family:Verdana;\"> Sound prognostic data in sepsis induced acute renal failure (SARF) are lacking
especially on the short term outcome [STO] in the intensive care unit [ICU]. We
addressed the use of Tc-99m DMSA [2,3-dimercaptosuc</span><span lang=\"EN-US\"><span style=\"font-family:Verdana;\">cinicacid] renal cortical imaging as a
prognostic tool in SARF. </span><span style=\"font-family:Verdana;\">Methods:</span><span style=\"font-family:Verdana;\"> Forty patients with acute renal failure due to sepsis [age range 15</span></span><span lang=\"EN-US\" style=\"font-family:Verdana;\">-</span><span lang=\"EN-US\"><span style=\"font-family:Verdana;\">74 years; median 44.5] were subjected
for full history taking complete physical examination, routine ICU monitoring,
routine laboratory investigations, APACHE II [Acute Physiology and Chronic Health
Evaluation] and SOFA [Sequential Organ Failure Assessment] together with Tc-99m
DMSA cortical renal scintigraphy. Patients¡¯ death in the ICU or discharge was
considered as the end point of the study representing the so-called short term
outcome [STO]. </span><span style=\"font-family:Verdana;\">Results:</span><span style=\"font-family:Verdana;\"> 25%
mortality rate [10/40] was found along the admission period in the ICU. All
non-survivors were abnormal with DMSA imaging [NPV &amp; PPV 100% &amp; 66.7%
respectively]. Abnormal DMSA cases showed significant positive associations
with serum creatinine at admission [r = 0.5; P 0.02]; admission duration [r = 0.4;
P 0.002]; APACHE II score [r = 0.5; P 0.004] and STO [r = 0.4; P 0.03].
Statistically significant difference was elicited between subjects with normal
and abnormal DMSA regarding the same parameters. </span><span style=\"font-family:Verdana;\">Conclusion:</span><span style=\"font-family:Verdana;\"> This preliminary data could raise Tc-99m DMSA renal
imaging as a prognostic tool in SARF that could allow influential interference
to prohibit dramatic outcomes as mortality.</span></span>
</p>
%K Acute Renal Failure
%K Tc-99m DMSA
%K Sepsis Induced Acute Renal Failure
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=41209