%0 Journal Article
%T Serum Ratio of Leptin to Adiponectin in Patients with Chronic Periodontitis and Type 2 Diabetes Mellitus
%A Xu Jing Ling
%A Meng Huan Xin
%A He Lu
%A Wang XianĄŻE
%A Zhang Lin
%J ISRN Biomarkers
%D 2014
%R 10.1155/2014/952636
%X Background. Serum ratio of leptin to adiponectin has been reported to be a useful index of insulin resistance. Since these two adipokines could also be involved in many immunoinflammatory reactions, this ratio might be associated with some inflammatory diseases such as periodontitis. The present study aims to explore the difference in serum ratio of leptin/adiponectin among patients with diabetes and periodontitis, patients with periodontitis only, and healthy people and find out the correlation between this ratio and periodontal parameters. Method. 15 patients with chronic periodontitis and type 2 diabetes, 15 patients with chronic periodontitis only, and 15 healthy controls were selected. Clinical indexes and periodontal parameters were recorded and serum leptin and adiponectin levels were tested by ELISA kits. Result. The ratio of leptin/adiponectin is significantly different among three groups; the T2 DM + CP group has the highest ratio ( ) and the healthy group has the lowest ratio ( ). What is more, the ratio of leptin/adiponectin has strong positive correlation with periodontal parameters ( ). Conclusions. Chronic periodontitis could influence the level of adipokines in serum and change the ratio of leptin/adiponectin, and the effect would be enhanced combining with type 2 diabetes. 1. Introduction Type 2 diabetes mellitus is a chronic metabolic disease because of insulin resistance, while obesity may be a very important factor associated with insulin resistance and type 2 diabetes mellitus [1]. Researches during the last 20 years showed that the adipose tissue, in addition to being a specialized organ for fat storage and release, should also be considered an active endocrine gland capable of synthesizing and secreting adipokines such as adiponectin and leptin [2]. These adipokines could not only affect the insulin sensitivity, but also be involved in many immunoinflammatory reactions [3]. Chronic periodontitis is an infective disease damaging the periodontal tissue, and the local host response to periodontal pathogens and their products is thought to play a crucial role during this process. Studies recently found that periodontitis might be related to several systemic diseases especially diabetes mellitus [4¨C6]. Chronic periodontitis and type 2 diabetes could influence themselves bidirectionally because of some common immunoinflammatory mechanisms and some common risk factors such as obesity [7]. Thus, Saito suggested that obesity, type 2 diabetes, and chronic periodontitis are closely associated, exhibiting a triangular relationship [8], and
%U http://www.hindawi.com/journals/isrn.biomarkers/2014/952636/