%0 Journal Article
%T Comparative Pharmacokinetics of Cefquinome (Cobactan 2.5%) following Repeated Intramuscular Administrations in Sheep and Goats
%A Mohamed El-Hewaity
%A Amera Abd El Latif
%A Ahmed Soliman
%A Mohamed Aboubakr
%J Journal of Veterinary Medicine
%D 2014
%R 10.1155/2014/949642
%X The comparative pharmacokinetic profile of cefquinome was studied in sheep and goats following repeated intramuscular (IM) administrations of 2£¿mg/kg body weight. Cefquinome concentrations in serum were determined by microbiological assay technique using Micrococcus luteus (ATCC 9341) as test organism. Following intramuscular injection of cefquinome in sheep and goats, the disposition curves were best described by two-compartment open model in both sheep and goats. The pharmacokinetics of cefquinome did not differ significantly between sheep and goats; similar intramuscular dose rate of cefquinome should therefore be applicable to both species. On comparing the data of serum levels of repeated intramuscular injections with first intramuscular injection, it was revealed that repeated intramuscular injections of cefquinome have cumulative effect in both species sheep and goats. The in vitro serum protein-binding tendency was 15.65% in sheep and 14.42% in goats. The serum concentrations of cefquinome along 24£¿h after injection in this study were exceeding the MICs of different susceptible microorganisms responsible for serious disease problems. These findings indicate successful use of cefquinome in sheep and goats. 1. Introduction Cephalosporins are described as -lactam antibiotics, based on their common structural feature, containing the -lactam ring. A major advantage of the -lactam antibiotics is high degree of safety in the target animal [1]. Cefquinome, an aminothiazolyl cephalosporin, is a member of the fourth-generation of cephalosporins that has been used for veterinary use only [2]. It has broad-spectrum antibacterial activity against clinically important bacteria such as streptococcus spp, staphylococcus spp, pseudomonas spp, E. coli, and gram-positive anaerobes [3, 4]. It has been approved for the treatment of respiratory diseases, acute mastitis, and foot rot in cattle [5, 6]. The objective of the current study is to determine whether there are differences between sheep and goat in the disposition of cefquinome following repeated intramuscular administrations of 2£¿mg/kg£¿b.wt. once daily for three consecutive days in sheep and goat, to determine if the drug has a cumulative effect after repeated intramuscular administrations and to recommend appropriate dose regimen for cefquinome in sheep and goat. 2. Materials and Methods 2.1. Antimicrobial Agent Cefquinome was obtained from Intervet International Company, Cairo, Egypt, under a trade name: Cobactan 2.5%. 2.2. Animals Five healthy nonlactating female Egyptian Baladi sheep (weighing
%U http://www.hindawi.com/journals/jvm/2014/949642/