%0 Journal Article
%T Trends in Pulmonary Hypertension Mortality and Morbidity
%A Alem Mehari
%A Orlando Valle
%A Richard F. Gillum
%J Pulmonary Medicine
%D 2014
%I Hindawi Publishing Corporation
%R 10.1155/2014/105864
%X Context. Few reports have been published regarding surveillance data for pulmonary hypertension, a debilitating and often fatal condition. Aims. We report trends in pulmonary hypertension. Settings and Design. United States of America; vital statistics, hospital data. Methods and Material. We used mortality data from the National Vital Statistics System (NVSS) for 1999每2008 and hospital discharge data from the National Hospital Discharge Survey (NHDS) for 1999每2009. Statistical Analysis Used. We present age-standardized rates. Results. Since 1999, the numbers of deaths and hospitalizations as well as death rates and hospitalization rates for pulmonary hypertension have increased. In 1999 death rates were higher for men than for women; however, by 2002, no differences by gender remained because of the increasing death rates among women and the declining death rates among men; after 2003 death rates for women were higher than for men. Death rates throughout the reporting period 1999每2008 were higher for blacks than for whites. Hospitalization rates in women were 1.3每1.6 times higher than in men. Conclusions. Pulmonary hypertension mortality and hospitalization numbers and rates increased from 1999 to 2008. 1. Introduction Pulmonary hypertension (PH) is a disorder of the pulmonary vasculature that results in increased pulmonary arterial pressure and is defined as a mean pulmonary arterial pressure (mPAP) ≡25ˋmmˋHg at rest, the pressure being measured invasively with a pulmonary artery catheter [1每4]. Despite improvements in the diagnosis and management of PH over the past 2 decades with the introduction of targeted medical therapies leading to improved survival, the disease continues to have a poor long-term prognosis [5]. US death rates for PH as the underlying cause of death increased between 1979 and 1999 [6每8]. To assess more recent trends, this report describes national trends for all PH-related deaths and hospitalizations during 1999每2008. 2. Subjects and Methods To examine trends in PH mortality, we analyzed data from the Centers for Disease Control (CDC) National Vital Statistics System (NVSS). The NVSS classified diseases and conditions reported on death certificates during 1999每2010 according to the International Classification of Diseases, Tenth Revision (ICD-10) codes for deaths [9每19]. For this analysis, we considered PH-associated deaths, those with ICD-10 codes I27.0, I27.8, or I27.9 during 1999每2002 and ICD-10 codes I27.0, I27.2, I27.8, or I27.9 during 2003每2008, as any contributing cause of death (i.e., any of the possible 20 conditions,
%U http://www.hindawi.com/journals/pm/2014/105864/