%0 Journal Article
%T Ectosomes: A New Mechanism for Non-Exosomal Secretion of Tau Protein
%A Simon Dujardin
%A S¨¦verine B¨¦gard
%A RaphaŁżlle Caillierez
%A C¨¦drick Lachaud
%A Lucie Delattre
%A S¨¦bastien Carrier
%A Anne Loyens
%A Marie-Christine Galas
%A Luc Bousset
%A Ronald Melki
%A GwennaŁżlle Aur¨¦gan
%A Philippe Hantraye
%A Emmanuel Brouillet
%A Luc Bu¨¦e
%A Morvane Colin
%J PLOS ONE
%D 2014
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0100760
%X Tau is a microtubule-associated protein that aggregates in neurodegenerative disorders known as tauopathies. Recently, studies have suggested that Tau may be secreted and play a role in neural network signalling. However, once deregulated, secreted Tau may also participate in the spreading of Tau pathology in hierarchical pathways of neurodegeneration. The mechanisms underlying neuron-to-neuron Tau transfer are still unknown; given the known role of extra-cellular vesicles in cell-to-cell communication, we wondered whether these vesicles could carry secreted Tau. We found, among vesicles, that Tau is predominately secreted in ectosomes, which are plasma membrane-originating vesicles, and when it accumulates, the exosomal pathway is activated.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0100760