%0 Journal Article
%T Synthesis of Tri- and Tetracycle Compounds via Reaction of 1,3-Decalinediones and 4-Hydroxycoumarines with 2-Acetyl-2-Cyclohexenes and Biological Testing
%A Anatoliyi N. Pyrko
%A Gennadiyi S. Lyubin
%A Stanislove L. Bondarev
%J Open Access Library Journal
%V 1
%N 4
%P 1-8
%@ 2333-9721
%D 2014
%I Open Access Library
%R 10.4236/oalib.1100749
%X <p class="MsoNormal">
	<span lang="EN-US">2-Acetyl-5,
5-dimethyl-2-cyclohexen-l-one reacts with decalin-1,3-dions (9a, b) and
4-hydroxy- coumarins (13a, b) following the pattern of a Michael addition with
the formation of tricyclic compounds (10a, b and 14a, b). In the case of
unsubstituted 2-acetyl-2-cyclohexen-l-one reaction with 4-hydroxycoumarine
follows pattern of a DieIs-Alder heterodiene condensation to form tetracycle
(15). Dehydration of both types of adduct gives tetracyclic compounds (11a, b
and 16a, b, c). Coumarine derivatives (14a, b, 15, 16c) were tested for
anticoagulative activity.</span>
</p>
%K Synthesis
%K decalindion and coumarine derivatives
%K anticoagulative activity
%U http://www.oalib.com/paper/3099384