%0 Journal Article
%T Cytotoxic Proteins and Therapeutic Targets in Severe Cutaneous Adverse Reactions
%A Shih-Chi Su
%A Wen-Hung Chung
%J Toxins
%D 2014
%I MDPI AG
%R 10.3390/toxins6010194
%X Severe cutaneous adverse reactions (SCARs), such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrosis (TEN), are rare but life-threatening conditions induced mainly by a variety of drugs. Until now, an effective treatment for SJS/TEN still remains unavailable. Current studies have suggested that the pathobiology of drug-mediated SJS and TEN involves major histocompatibility class (MHC) I-restricted activation of cytotoxic T lymphocytes (CTLs) response. This CTLs response requires several cytotoxic signals or mediators, including granulysin, perforin/granzyme B, and Fas/Fas ligand, to trigger extensive keratinocyte death. In this article, we will discuss the cytotoxic mechanisms of severe cutaneous adverse reactions and their potential applications on therapeutics for this disease.
%K Stevens-Johnson syndrome
%K toxic epidermal necrosis
%K granulysin
%K perforin
%K granzyme B
%K Fas/Fas ligand
%U http://www.mdpi.com/2072-6651/6/1/194