%0 Journal Article
%T Incorporating ¦Â-Cyclodextrin with ZnO Nanorods: A Potentiometric Strategy for Selectivity and Detection of Dopamine
%A Sami Elhag
%A Zafar Hussain Ibupoto
%A Omer Nur
%A Magnus Willander
%J Sensors
%D 2014
%I MDPI AG
%R 10.3390/s140101654
%X We describe a chemical sensor based on a simple synthesis of zinc oxide nanorods (ZNRs) for the detection of dopamine molecules by a potentiometric approach. The polar nature of dopamine leads to a change of surface charges on the ZNR surface via metal ligand bond formation which results in a measurable electrical signal. ZNRs were grown on a gold-coated glass substrate by a low temperature aqueous chemical growth (ACG) method. Polymeric membranes incorporating ¦Â-cyclodextrin (¦Â-CD) and potassium tetrakis (4-chlorophenyl) borate was immobilized on the ZNR surface. The fabricated electrodes were characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM) techniques. The grown ZNRs were well aligned and exhibited good crystal quality. The present sensor system displays a stable potential response for the detection of dopamine in 10 £¿2 mol¡¤L £¿1 acetic acid/sodium acetate buffer solution at pH 5.45 within a wide concentration range of 1 ¡Á 10 £¿6 M ¨C1 ¡Á 10 £¿1 M, with sensitivity of 49 mV/decade. The electrode shows a good response time (less than 10 s) and excellent repeatability. This finding can contribute to routine analysis in laboratories studying the neuropharmacology of catecholamines. Moreover, the metal-ligand bonds can be further exploited to detect DA receptors, and for bio-imaging applications.
%K ZnO nanorods
%K dopamine
%K potentiometric response
%K selectivity
%K stability
%K repeatability
%U http://www.mdpi.com/1424-8220/14/1/1654