%0 Journal Article
%T Mycobacterium tuberculosis DNA Detection Using Surface Plasmon Resonance Modulated by Telecommunication Wavelength
%A Shih-Hsiang Hsu
%A Yan-Yu Lin
%A Shao-Hsi Lu
%A I-Fang Tsai
%A Yen-Ta Lu
%A Hsin-Tsung Ho
%J Sensors
%D 2014
%I MDPI AG
%R 10.3390/s140100458
%X A surface plasmon resonance sensor for Mycobacterium tuberculosis ( MTB) deoxyribonucleic acid (DNA) is developed using repeatable telecommunication wavelength modulation based on optical fiber communications laser wavelength and stability. MTB DNA concentrations of 1 ¦Ìg/mL and 10 ¦Ìg/mL were successfully demonstrated to have the same spectral half-width in the dip for optimum coupling. The sensitivity was shown to be £¿0.087 dB/(¦Ìg/mL) at all applied telecommunication wavelengths and the highest sensitivity achieved was 115 ng/mL without thiolated DNA immobilization onto a gold plate, which is better than the sensor limit of 400 ng/mL possible with commercial biosensor equipment.
%K Mycobacterium tuberculosis
%K surface plasmon resonance
%K wavelength modulation
%U http://www.mdpi.com/1424-8220/14/1/458