%0 Journal Article
%T Real-Time Label-Free Surface Plasmon Resonance Biosensing with Gold Nanohole Arrays Fabricated by Nanoimprint Lithography
%A Josu Martinez-Perdiguero
%A Aritz Retolaza
%A Deitze Otaduy
%A Aritz Juarros
%A Santos Merino
%J Sensors
%D 2013
%I MDPI AG
%R 10.3390/s131013960
%X In this work we present a surface plasmon resonance sensor based on enhanced optical transmission through sub-wavelength nanohole arrays. This technique is extremely sensitive to changes in the refractive index of the surrounding medium which result in a modulation of the transmitted light. The periodic gold nanohole array sensors were fabricated by high-throughput thermal nanoimprint lithography. Square periodic arrays with sub-wavelength hole diameters were obtained and characterized. Using solutions with known refractive index, the array sensitivities were obtained. Finally, protein absorption was monitored in real-time demonstrating the label-free biosensing capabilities of the fabricated devices.
%K label-free
%K biosensor
%K surface plasmon resonance
%K nanohole array
%K nanoimprint lithography
%U http://www.mdpi.com/1424-8220/13/10/13960