%0 Journal Article
%T The Flux of Phenolic Compounds through Silicone Membranes
%A John Prybylski
%A Kenneth B. Sloan
%J Pharmaceutics
%D 2013
%I MDPI AG
%R 10.3390/pharmaceutics5030434
%X Phenols as a class of molecules have been reported to exhibit higher log maximum fluxes through human stratum corneum, SC, from water, log J MHAQ, than other classes of molecules. This suggests that their corresponding log maximum fluxes through silicone from water, log J MPAQ, may be useful to extend the existing n = 63 log J MPAQ database to include more log J MPAQ values greater than 0.0. The log J MPAQ values for n = 7 phenols predicted to give log J MPAQ values greater than 0.0 based on their log J MHAQ values have been experimentally determined. These n = 7 new log J MPAQ values have been added to the existing n = 63 log J MPAQ database to give a new n = 70 database and the n = 7 literature log J MHAQ values have been added to the existing n = 48 log J MHAQ database (matched to the n = 63 log J MPAQ database) to give a new n = 55 database. The addition of the n = 7 phenols improved the correlations of these flux databases when fitted to the Roberts-Sloan equation, RS, as well as the correlation between the matched experimental (Exp.) log J MPAQ with the Exp. log J MHAQ.
%K maximum flux
%K silicone membrane
%K Roberts¨CSloan equation
%K water solubility
%K lipid solubility
%K human skin in vitro
%U http://www.mdpi.com/1999-4923/5/3/434