%0 Journal Article
%T Impact of Short Term Consumption of Diets High in Either Non-Starch Polysaccharides or Resistant Starch in Comparison with Moderate Weight Loss on Indices of Insulin Sensitivity in Subjects with Metabolic Syndrome
%A Gerald E. Lobley
%A Grietje Holtrop
%A David M. Bremner
%A A. Graham Calder
%A Eric Milne
%A Alexandra M. Johnstone
%J Nutrients
%D 2013
%I MDPI AG
%R 10.3390/nu5062144
%X This study investigated if additional non-starch polysaccharide (NSP) or resistant starch (RS), above that currently recommended, leads to better improvement in insulin sensitivity (IS) than observed with modest weight loss (WL). Obese male volunteers ( n = 14) were given an energy-maintenance (M) diet containing 27 g NSP and 5 g RS daily for one week. They then received, in a cross-over design, energy-maintenance intakes of either an NSP-enriched diet (42 g NSP, 2.5 g RS) or an RS-enriched diet (16 g NSP, 25 g RS), each for three weeks. Finally, a high protein (30% calories) WL diet was provided at 8 MJ/day for three weeks. During each dietary intervention, endogenous glucose production (EGP) and IS were assessed. Fasting glycaemia was unaltered by diet, but plasma insulin and C-peptide both decreased with the WL diet ( p < 0.001), as did EGP (£¿11%, p = 0.006). Homeostatis model assessment of insulin resistance improved following both WL ( p < 0.001) and RS ( p < 0.05) diets. Peripheral tissue IS improved only with WL (57%¨C83%, p < 0.005). Inclusion of additional RS or NSP above amounts currently recommended resulted in little or no improvement in glycaemic control, whereas moderate WL (approximately 3 kg fat) improved IS.
%K insulin sensitivity
%K stable isotope kinetics
%K non-starch polysaccharides
%K resistant starch
%K weight loss
%K Minimal Models
%K metabolic syndrome
%U http://www.mdpi.com/2072-6643/5/6/2144