%0 Journal Article
%T Oats in the Diet of Children with Celiac Disease: Preliminary Results of a Double-Blind, Randomized, Placebo-Controlled Multicenter Italian Study
%A Simona Gatti
%A Nicole Caporelli
%A Tiziana Galeazzi
%A Ruggiero Francavilla
%A Maria Barbato
%A Paola Roggero
%A Basilio Malamisura
%A Giuseppe Iacono
%A Andrea Budelli
%A Rosaria Gesuita
%A Carlo Catassi
%A Elena Lionetti
%J Nutrients
%D 2013
%I MDPI AG
%R 10.3390/nu5114653
%X A gluten-free diet (GFD) is currently the only available treatment for patients with celiac disease (CD). Several clinical trials have demonstrated that most celiac patients can tolerate a medium-high quantity of oats without any negative clinical effects; however, the inclusion of oats in GFD is still a matter of debate. In this study, Italian children with CD were enrolled in a 15-month, randomized, double-blind, placebo-controlled multicenter trial. Participants were randomized in two groups following either A-B treatment (6 months of diet Ħ°AĦħ, 3 months of standard GFD, 6 months of diet Ħ°BĦħ), or B-A treatment (6 months of diet Ħ°BĦħ, 3 months of standard GFD, 6 months of diet Ħ°AĦħ). A and B diets included gluten-free (GF) products (flour, pasta, biscuits, cakes and crisp toasts) with either purified oats or placebo. Clinical data (Gastrointestinal Symptoms Rate Scale [GSRS] score) and intestinal permeability tests (IPT), were measured through the study period. Although the study is still blinded, no significant differences were found in GSRS score or the urinary lactulose/mannitol (L/M) ratio between the two groups after 6 months of treatment. These preliminary results suggest that the addition of non-contaminated oats from selected varieties in the treatment of children with CD does not determine changes in intestinal permeability and gastrointestinal symptoms.
%K oats
%K celiac disease
%K gluten-free diet
%K intestinal permeability
%K gastrointestinal symptoms
%U http://www.mdpi.com/2072-6643/5/11/4653