%0 Journal Article
%T Diastereoselective Three-Component Reactions of Chiral Nickel(II) Glycinate for Convenient Synthesis of Novel ¦Á-Amino-¦Â-Substituted-¦Ã,¦Ã-Disubstituted Butyric Acids
%A Rui Zhou
%A Li Guo
%A Cheng Peng
%A Gu He
%A Liang Ouyang
%A Wei Huang
%J Molecules
%D 2014
%I MDPI AG
%R 10.3390/molecules19010826
%X The convenient, high yielding and diastereoselective synthesis of ¦Á-amino-¦Â-substituted-¦Ã,¦Ã-disubstituted butyric acid derivatives was carried out by a three-component tandem reaction of a chiral equivalent of nucleophilic glycine. The reaction was performed smoothly under mild conditions and enabled the construction of two or three adjacent chiral centers in one step, thus affording a novel and convenient route to ¦Á-amino-¦Â-substituted-¦Ã,¦Ã-disubstituted butyric acid derivatives.
%K multi-component reaction
%K nickel(II)
%K glycine
%K diastereoselectivity
%K unnatural amino acids
%U http://www.mdpi.com/1420-3049/19/1/826