%0 Journal Article
%T Hormesis of Glyceollin I, an Induced Phytoalexin from Soybean, on Budding Yeast Chronological Lifespan Extension
%A Yuancai Liu
%A Ziyun Wu
%A Shengbao Feng
%A Xuena Yang
%A Dejian Huang
%J Molecules
%D 2014
%I MDPI AG
%R 10.3390/molecules19010568
%X Glyceollin I, an induced phytoalexin isolated from soybean, has been reported to have various bioactivities, including anti-bacterial, anti-nematode, anti-fungal, anti-estrogenic and anti-cancer, anti-oxidant, anti-inflammatory, insulin sensitivity enhancing, and attenuation of vascular contractions. Here we show that glyceollin I has hormesis and extends yeast life span at low (nM) doses in a calorie restriction (CR)-dependent manner, while it reduces life span and inhibits yeast cell proliferation at higher (¦ÌM) doses. In contrast, the other two isomers (glyceollin II and III) cannot extend yeast life span and only show life span reduction and antiproliferation at higher doses. Our results in anti-aging activity indicate that glyceollin I might be a promising calorie restriction mimetic candidate, and the high content of glyceollins could improve the bioactivity of soybean as functional food ingredients.
%K chronological life span
%K glyceollin I
%K hormesis
%K induced phytoalexin
%K aging
%U http://www.mdpi.com/1420-3049/19/1/568