%0 Journal Article
%T The Phenolics from the Roots of Livistona chinensis Show Antioxidative and Obsteoblast Differentiation Promoting Activity
%A Xiaobin Zeng
%A Jun Tian
%A Liao Cui
%A Yang Wang
%A Yanjie Su
%A Xin Zhou
%A Xiangjiu He
%J Molecules
%D 2014
%I MDPI AG
%R 10.3390/molecules19010263
%X This study investigated the antioxidative and obsteoblast differentiation promoting activity of the phenolics isolated from the 70% ethanol extract of the roots of Livistona chinensis. Two new phenolics, (2 R,3 R)-3,5,6,7,3',4'-hexahydroxyflavane ( 1), and phenanthrene-2,4,9-triol ( 2), together with six known phenolics 3每 8, were isolated and identified on the basis of extensive spectroscopic analysis. The antioxidative and obsteoblast differentiation promoting abilities of the compounds 1每 3, 7每 8 were tested, the phenolics 1每 3, 7 showed effects on proliferation of osteoblastic cells and antioxidative activity of 3.125每50 米g/mL. In addition, the phenolics 1每 3 observably increased alkaline phosphatase activity, osteocalcin content and hydroxyproline content in osteoblastic cells. Phenolic 1 at 12.5 米g/mL concentration significantly increased the area of nodules by about 9.35-fold. The antioxidative activity results indicated that the anti-osteoporosis effects of these phenolics may be linked to a reduction of oxidative stress. The observed effects of these phenolics on bone formation by rat osteoblastic cells suggest that these phenolics may have beneficial effects on bone health.
%K phenolic
%K flavane
%K Livistona chinensis
%K osteoporosis
%K oxidative stress
%U http://www.mdpi.com/1420-3049/19/1/263