%0 Journal Article
%T Recent Syntheses of 1,2,3,4-Tetrahydroquinolines, 2,3-Dihydro-4(1H)-quinolinones and 4(1H)-Quinolinones using Domino Reactions
%A Baskar Nammalwar
%A Richard A. Bunce
%J Molecules
%D 2014
%I MDPI AG
%R 10.3390/molecules19010204
%X A review of the recent literature is given focusing on synthetic approaches to 1,2,3,4-tetrahydroquinolines, 2,3-dihydro-4(1 H)-quinolinones and 4(1 H)-quinolinones using domino reactions. These syntheses involve: (1) reduction or oxidation followed by cyclization; (2) S NAr-terminated sequences; (3) acid-catalyzed ring closures or rearrangements; (4) high temperature cyclizations and (5) metal-promoted processes as well as several less thoroughly studied reactions. Each domino method is presented with a brief discussion of mechanism, scope, yields, simplicity and potential utility.
%K domino reaction
%K tandem reaction
%K cascade reaction
%K 1
%K 2
%K 3
%K 4-tetrahydroquinoline
%K 2
%K 3-dihydro-4(1H)-quinolinone
%K 4(1H)-quinolinone
%K heterocycle synthesis
%K drug synthesis
%U http://www.mdpi.com/1420-3049/19/1/204