%0 Journal Article
%T Asymmetric Synthesis of 4,1-Benzoxazepine-2,5-Diones ¡ª Effect of the Halogen of (2S)-¦Á-Haloacids
%A Syeda Laila Rubab
%A Bushra Nisar
%A Abdul Rauf Raza
%A Nisar Ullah
%A Muhammad Nawaz Tahir
%J Molecules
%D 2014
%I MDPI AG
%R 10.3390/molecules19010139
%X Novel chiral 4,1-benzoxazepine-2,5-diones have been unusually synthesized in a single step by exploiting the chiral pool methodology. Substituted anthranilic acids afford N-acylanthranilic acids and (3 R)-3-alkyl-4,1-benzoxazepines-2,5-dione upon coupling with ¦Á-chloroacids or ¦Á-bromoacids, respectively.
%K (3R)-3-alkyl-4
%K 1-benzoxazepine-2
%K 5-diones
%K asymmetric synthesis
%K ¦Á-chloroacids
%K ¦Á-bromoacids
%K anthranilic acid
%K chiral pool methodology
%U http://www.mdpi.com/1420-3049/19/1/139