%0 Journal Article
%T Phenolic Glucosides from Dendrobium aurantiacum var. denneanum and Their Bioactivities
%A Liang Xiong
%A Zhi-Xing Cao
%A Cheng Peng
%A Xiao-Hong Li
%A Xiao-Fang Xie
%A Ting-Mo Zhang
%A Qin-Mei Zhou
%A Lian Yang
%A Li Guo
%J Molecules
%D 2013
%I MDPI AG
%R 10.3390/molecules18066153
%X A new 8,4¡é-oxyneolignane glucoside 1 has been isolated from the stems of Dendrobium aurantiacum var. denneanum together with six known phenolic glucosides 2- 7. The structure of the new compound, including its absolute configuration, was determined by spectroscopic and chemical methods as (¨C)-(7 S,8 R,7¡é E)-4-hydroxy-3,3¡é,5,5¡é-tetramethoxy-8,4¡é-oxyneolign-7¡é-ene-7,9,9¡é-triol 7,9¡é-bis- O- ¦Â-D-glucopyranoside ( 1). In the in vitro assays, compound 1 and (-)-syringaresinol-4,4¡é-bis- O- ¦Â-D-glucopyranoside ( 2) showed evident activity against glutamate-induced neurotoxicity in PC12 cells. Shashenoside I ( 4) showed a selective cytotoxic activity with the IC 50 value of 4.17 ¦ÌM against the acute myeloid leukemia cell line MV4-11, while it was inactive against 10 other human tumor cell lines.
%K Dendrobium aurantiacum var. denneanum
%K lignan glucosides
%K phenylpropanoid glycosides
%K bioactivities
%U http://www.mdpi.com/1420-3049/18/6/6153