%0 Journal Article
%T One-Pot Synthesis of Novel Chiral ¦Â-Amino Acid Derivatives by Enantioselective Mannich Reactions Catalyzed by Squaramide Cinchona Alkaloids
%A Kankan Zhang
%A Xueping Liang
%A Ming He
%A Jian Wu
%A Yuping Zhang
%A Wei Xue
%A Linhong Jin
%A Song Yang
%A Deyu Hu
%J Molecules
%D 2013
%I MDPI AG
%R 10.3390/molecules18066142
%X An ef£¿cient one-pot synthesis of novel ¦Â-amino acid derivatives containing a thiadiazole moiety was developed using a chiral squaramide cinchona alkaloid as organocatalyst. The reactions afforded chiral ¦Â-amino acid derivatives in moderate yields and with moderate to excellent enantioselectivities. The present study demonstrated for the first time the use of a Mannich reaction catalyzed by a chiral bifunctional organocatalyst for the one-pot synthesis of novel ¦Â-amino acid derivatives bearing a 1,3,4-thiadiazole moiety on nitrogen.
%K Asymmetric Mannich addition
%K ¦Â-amino acid derivatives
%K 1
%K 3
%K 4-thiadiazole moiety
%K thiourea derived from squaramide cinchona alkaloid
%U http://www.mdpi.com/1420-3049/18/6/6142