%0 Journal Article
%T Synthesis of Tricyclic Condensed Rings Incorporating the Pyrazole or Isoxazole Moieties Bonded to a 4-Piperidinyl Substituent
%A Giansalvo Pinna
%A Giovanni Loriga
%A G¨Śrard A. Pinna
%A Giorgio Chelucci
%J Molecules
%D 2013
%I MDPI AG
%R 10.3390/molecules18078147
%X In this paper we report the synthesis of new compounds based on the pyrazole and isoxazole framework fused to a cycloalkene unit, and bearing as a substituent the 1-piperidinyl group as new examples of potential antipsychotic molecules. The general synthesis involves the acylation of a chloro-substituted cyclic ketone with a 1-substituted piperidine-4-carboxylate derivative, followed by heterocyclization of the formed 1,3-dioxo compound with a hydrazine or hydroxylamine.
%K heterocyclization
%K hydrazine
%K hydroxylamine
%K tricyclic isoxazoles
%K tricyclic pyrazoles
%U http://www.mdpi.com/1420-3049/18/7/8147