%0 Journal Article %T Protection of Astaxanthin in Astaxanthin Nanodispersions Using Additional Antioxidants %A Navideh Anarjan %A Imededdine Arbi Nehdi %A Chin Ping Tan %J Molecules %D 2013 %I MDPI AG %R 10.3390/molecules18077699 %X The protective effects of ¦Á-tocopherol and ascorbic acid on astaxanthin in astaxanthin nanodispersions produced via a solvent-diffusion technique and stabilized by a three-component stabilizer system, were studied either individually or in combination by using response surface methodology. Generally, both ¦Á-tocopherol and ascorbic acid could retard the astaxanthin degradation in astaxanthin nanodispersions. The results showed that the using ¦Á-tocopherol and ascorbic acid can be more efficient in increasing the chemical stability of nanodispersions in comparison to using them individually. Using a response surface methodology (RSM) response optimizer, it was seen that addition of ascorbic acid (ascorbic acid/astaxanthin w/w) and ¦Á-tocopherol (¦Á-tocopherol/astaxanthin w/w) in proportions of 0.4 and 0.6, respectively, would give the maximum chemical stability to the studied astaxanthin nanodispersions. %K astaxanthin nanodispersions %K chemical stability %K ascorbic acid %K ¦Á-tocopherol %U http://www.mdpi.com/1420-3049/18/7/7699