%0 Journal Article
%T Isolation and Synthesis of a Bioactive Benzenoid Derivative from the Fruiting Bodies of Antrodia camphorata
%A Pi-Yu Chen
%A Jen-Der Wu
%A Kai-Yih Tang
%A Chieh-Chou Yu
%A Yueh-Hsiung Kuo
%A Wen-Bin Zhong
%A Ching-Kuo Lee
%J Molecules
%D 2013
%I MDPI AG
%R 10.3390/molecules18077600
%X A new enynyl-benzenoid, antrocamphin O (1,4,7-dimethoxy-5-methyl-6-(3กไ-methylbut-3-en-1-ynyl)benzo[d][1,3]dioxide), and the known benzenoids antrocamphin A and 7-dimethoxy-5-methyl-1,3-benzodioxole, were isolated from the fruiting bodies of Antrodia camphorata ( Taiwanofungus camphoratus). The structure of antrocamphin O was unambiguously assigned by the analysis of spectral data (including 1D and 2D NMR, high-resolution MS, IR, and UV) and total synthesis. Compound 1 was prepared through the Sonogashira reaction of 5-iodo-4,7-dimethoxy-6-methylbenzene and 2-methylbut-1-en-3-yne as the key step. The benzenoids were tested for cytotoxicity against the HT29, HTC15, DLD-1, and COLO 205 colon cancer cell lines, and activities are reported herein.
%K Antrodia camphorata
%K enynyl-benzenoid
%K antrocamphin O
%K synthesis
%K cytotoxic activity
%U http://www.mdpi.com/1420-3049/18/7/7600