%0 Journal Article
%T Synthesis of New Acadesine (AICA-riboside) Analogues Having Acyclic d-Ribityl or 4-Hydroxybutyl Chains in Place of the Ribose
%A Stefano D'Errico
%A Giorgia Oliviero
%A Nicola Borbone
%A Jussara Amato
%A Vincenzo Piccialli
%A Michela Varra
%A Luciano Mayol
%A Gennaro Piccialli
%J Molecules
%D 2013
%I MDPI AG
%R 10.3390/molecules18089420
%X The antiviral activity of certain acyclic nucleosides drew our attention to the fact that the replacement of the furanose ring by an alkyl group bearing hydroxyl(s) could be a useful structural modification to modulate the biological properties of those nucleosides. Herein, we report on the synthesis of some novel acadesine analogues, where the ribose moiety is mimicked by a d-ribityl or by a hydroxybutyl chain.
%K AICAR
%K ZMP
%K acadesine
%K AMPK
%K AMPK activation
%K imidazole nucleosides
%K nucleoside analogues
%K modified nucleosides
%K acyclic nucleosides
%K acyclic nucleotides
%U http://www.mdpi.com/1420-3049/18/8/9420