%0 Journal Article
%T An Azabisphosphonate-Capped Poly(phosphorhydrazone) Dendrimer for the Treatment of Endotoxin-Induced Uveitis
%A S¨¦verine Fruchon
%A Anne-Marie Caminade
%A Claire Abadie
%A Jean-Luc Davignon
%A Jean-Marc Combette
%A C¨¦dric-Olivier Turrin
%A R¨¦my Poupot
%J Molecules
%D 2013
%I MDPI AG
%R 10.3390/molecules18089305
%X Over the last decade, different types of dendrimers have shown anti-inflammatory properties in their own right. In particular, we have shown that poly(phosphorhydrazone) (PPH) dendrimers are able to foster an efficient anti-inflammatory response in human monocytes and can resolve the main physiopathological features of chronic arthritis in mice at 1 mg/kg. Here we afford new insights into the therapeutic potential of an azabisphosphonate-capped dendrimer (dendrimer ABP). We have challenged its anti-inflammatory and immuno-modulatory properties in a robust rat model of acute uveitis induced by lipopolysaccharide (LPS). We show that dendrimer ABP at 2 ¦Ìg/eye is as efficient as the ¡°gold standard¡± dexamethasone at 20 ¦Ìg/eye. We have demonstrated that the effect of dendrimer ABP is mediated at least through an increase of the production of the anti-inflammatory Interleukin(IL)-10 cytokine.
%K PPH [poly(phosphorhydrazone)] dendrimer
%K anti-inflammatory
%K uveitis
%K toxicity
%U http://www.mdpi.com/1420-3049/18/8/9305