%0 Journal Article
%T Synthesis and Characterization of Some New Cu(II), Ni(II) and Zn(II) Complexes with Salicylidene Thiosemicarbazones: Antibacterial, Antifungal and in Vitro Antileukemia Activity
%A Elena Pahontu
%A Valeriu Fala
%A Aurelian Gulea
%A Donald Poirier
%A Victor Tapcov
%A Tudor Rosu
%J Molecules
%D 2013
%I MDPI AG
%R 10.3390/molecules18088812
%X Thirty two new Cu(II), Ni(II) and Zn(II) complexes ( 1¨C 32) with salicylidene thiosemicarbazones ( H2L1¨C H2L 10) were synthesized. Salicylidene thiosemicarbazones, of general formula (X)N-NH-C(S)-NH(Y), were prepared through the condensation reaction of 2-hydroxybenzaldehyde and its derivatives (X) with thiosemicarbazide or 4-phenylthiosemicarbazide (Y = H, C 6H 5). The characterization of the new formed compounds was done by 1H-NMR, 13C-NMR, IR spectroscopy, elemental analysis, magnetochemical, thermoanalytical and molar conductance measurements. In addition, the structure of the complex 5 has been determined by X-ray diffraction method. All ligands and metal complexes were tested as inhibitors of human leukemia (HL-60) cells growth and antibacterial and antifungal activities.
%K copper
%K nickel
%K zinc complexes
%K thiosemicarbazones
%K antimicrobial activity
%K antileukemia
%U http://www.mdpi.com/1420-3049/18/8/8812