%0 Journal Article
%T 3-Bromo-1-Hydroxy-9,10-Anthraquinone (BHAQ) Inhibits Growth and Migration of the Human Breast Cancer Cell Lines MCF-7 and MDA-MB231
%A Nadiah Abu
%A M. Nadeem Akhtar
%A Wan Yong Ho
%A Swee Keong Yeap
%A Noorjahan Banu Alitheen
%J Molecules
%D 2013
%I MDPI AG
%R 10.3390/molecules180910367
%X Breast cancer is becoming more prominent in women today. As of now, there are no effective treatments in treating metastatic breast cancer. We have tested the cytotoxic and anti-migration effects of BHAQ, a synthesized anthraquinone, on two breast cancer cell lines, MCF-7 and MDA-MB231. Anthraquinones are an interesting class of molecules that display a wide spectrum of biological applications, including anticancer properties. Cellular inhibition was tested through a MTT assay, double acridine orange/propidium iodide staining and FACS cell cycle analysis. Inhibition of migration was tested by the wound healing method, and migration through a Boyden chamber. BHAQ was cytotoxic towards both cell lines in a dose dependent and possibly cell-dependent manner. Additionally, BHAQ also inhibited the migration of the highly metastatic MDA-MB231 cell line.
%K anthraquinone
%K BHAQ
%K cytotoxic
%K MDA-MB231
%K MCF-7
%K migration
%U http://www.mdpi.com/1420-3049/18/9/10367