%0 Journal Article
%T Glycosyl-Nucleolipids as New Bioinspired Amphiphiles
%A Laurent Latxague
%A Amit Patwa
%A Eric Amigues
%A Philippe Barth¨Śl¨Śmy
%J Molecules
%D 2013
%I MDPI AG
%R 10.3390/molecules181012241
%X Four new Glycosyl-NucleoLipid (GNL) analogs featuring either a single fluorocarbon or double hydrocarbon chains were synthesized in good yields from azido thymidine as starting material. Physicochemical studies (surface tension measurements, differential scanning calorimetry) indicate that hydroxybutanamide-based GNLs feature endothermic phase transition temperatures like the previously reported double chain glycerol-based GNLs. The second generation of GNFs featuring a free nucleobase reported here presents a better surface activity (lower g lim) compared to the first generation of GNFs.
%K nucleolipid
%K nucleoside
%K glycosyl
%K fluorocarbon
%K amphiphiles
%K surface tension
%U http://www.mdpi.com/1420-3049/18/10/12241