%0 Journal Article
%T Pd0-Catalyzed Methyl Transfer on Nucleosides and Oligonucleotides, Envisaged as a PET Tracer
%A Damien James
%A Jean-Marc Escudier
%A Magali Szlosek-Pinaud
%A Eric Fouquet
%J Molecules
%D 2013
%I MDPI AG
%R 10.3390/molecules181113654
%X The methyl transfer reaction from activated monomethyltin, via a modified Stille coupling reaction, was studied under ˇ°ligandlessˇ± conditions on fully deprotected 5'-modified nucleosides and one dinucleotide. The reaction was optimized to proceed in a few minutes and quantitative yield, even under dilute conditions, thus affording a rapid and efficient new method for oligonucleotide labelling with carbon-11.
%K Stille coupling
%K nucleosides
%K oligonucleotides
%K methyl transfer
%K Positron Emission Tomography
%U http://www.mdpi.com/1420-3049/18/11/13654