%0 Journal Article
%T Clean and Efficient Synthesis of Isoxazole Derivatives in Aqueous Media
%A Guolan Dou
%A Pan Xu
%A Qiang Li
%A Yukun Xi
%A Zhibin Huang
%A Daqing Shi
%J Molecules
%D 2013
%I MDPI AG
%R 10.3390/molecules181113645
%X A series of 5-arylisoxazole derivatives were synthesized via the reaction of 3-(dimethyl-amino)-1-arylprop-2-en-1-ones with hydroxylamine hydrochloride in aqueous media without using any catalyst. This method has the advantages of easier work-up, mild reaction conditions, high yields, and an environmentally benign procedure.
%K 5-arylisoxazole
%K without catalyst
%K aqueous media
%K synthesis
%U http://www.mdpi.com/1420-3049/18/11/13645