%0 Journal Article
%T Synthesis, Characterization, X-ray Structure and Biological Activities of C-5-Bromo-2-hydroxyphenylcalix[4]-2-methyl resorcinarene
%A Hamza M. Abosadiya
%A Siti Aishah Hasbullah
%A Mukram Mohamed Mackeen
%A Seow Chew Low
%A Nazlina Ibrahim
%A Mamoru Koketsu
%A Bohari M. Yamin
%J Molecules
%D 2013
%I MDPI AG
%R 10.3390/molecules181113369
%X C-5-bromo-2-hydroxyphenylcalix[4]-2-methylresorcinarene ( I) was synthesized by cyclocondensation of 5-bromo-2-hydroxybenzaldehyde and 2-methylresorcinol in the presence of concentrated HCl. Compound I was characterized by infrared and nuclear magnetic resonance spectroscopic data. X-ray analysis showed that this compound crystallized in a triclinic system with space group of P¨©, a = 15.9592(16)£¿, b = 16.9417(17)£¿, c = 17.0974(17)£¿, ¦Á = 68.656(3)¡ã, ¦Â = 85.689(3)¡ã, ¦Ã = 81.631(3)¡ã, Z = 2 and V = 4258.6(7)£¿ 3. The molecule adopts a chair (C 2h) conformation. The thermal properties and antioxidant activity were also investigated. It was strongly antiviral against HSV-1 and weakly antibacterial against Gram-positive bacteria. Cytotoxicity testing on Vero cells showed that it is non-toxic, with a CC 50 of more than 0.4 mg/mL.
%K C-5-bromo-2-hydroxyphenylcalix[4]-2-methylresorcinarene
%K biological activities
%K X-ray structural study
%U http://www.mdpi.com/1420-3049/18/11/13369