%0 Journal Article
%T Construction of a Novel Magnetic Targeting Anti-Tumor Drug Delivery System: Cytosine Arabinoside-Loaded Bacterial Magnetosome
%A Qiongjia Deng
%A Yuangang Liu
%A Shibin Wang
%A Maobin Xie
%A Shenjian Wu
%A Aizheng Chen
%A Wenguo Wu
%J Materials
%D 2013
%I MDPI AG
%R 10.3390/ma6093755
%X To ease the side effects triggered by cytosine arabinoside (Ara-C) for acute leukemia treatment, a novel magnetic targeting anti-tumor drug delivery system was constructed through bacterial magnetosomes (BMs) from Magnetospirillum magneticum AMB-1 combined with Ara-C by crosslinking of genipin (GP). The results showed that Ara-C could be bonded onto the membrane surface of BMs effectively through chemical crosslinking induced by dual hand reagents GP. The average diameters of BMs and Ara-C-coupled BMs (ABMs) were 42.0 ¡À 8.6 and 72.7 ¡À 6.0 nm respectively, and the zeta potentials (£¿38.1 ¡À 9.1) revealed that these systems were stable, confirming the stability of the system. The optimal encapsulation efficiency and drug loading were 89.05% ¡À 2.33% and 47.05% ¡À 0.64% respectively when crosslinking reaction lasted for 72 h. The system also presented long-term stability and release behaviors without initial burst release (Ara-C could be released 80% within three months). Our results indicate that BMs have great potential in biomedical and clinical fields as a novel anti-tumor drug carrier.
%K cytosine arabinoside
%K magnetosome
%K genipin
%K drug release
%U http://www.mdpi.com/1996-1944/6/9/3755