%0 Journal Article
%T Induced Marine Fungus Chondrostereum sp. as a Means of Producing New Sesquiterpenoids Chondrosterins I and J by Using Glycerol as the Carbon Source
%A Hou-Jin Li
%A Wen-Han Jiang
%A Wan-Ling Liang
%A Jia-Xin Huang
%A Yu-Fei Mo
%A Yan-Qing Ding
%A Chi-Keung Lam
%A Xiao-Jun Qian
%A Xiao-Feng Zhu
%A Wen-Jian Lan
%J Marine Drugs
%D 2014
%I MDPI AG
%R 10.3390/md12010167
%X Chondrostereum sp., a marine fungus isolated from a soft coral Sarcophyton tortuosum, can yield hirsutane framework sesquiterpenoids. However, the metabolites profiles vary dramatically with the composition change of the culture media. This fungus was cultured in a liquid medium containing glycerol as the carbon source, and two new metabolites, chondrosterins I and J ( 1 and 2), were obtained. Their structures were elucidated primarily based on MS, NMR and X-ray single-crystal diffraction data. By comparison with the known hirsutane sesquiterpenoids, chondrosterins I and J have unique structural features, including a methyl was migrated from C-2 to C-6, and the methyl at C-3 was carboxylated. Compound 2 exhibited potent cytotoxic activities against the cancer cell lines CNE-1 and CNE-2 with the IC 50 values of 1.32 and 0.56 ¦ÌM.
%K marine fungus
%K Chondrostereum sp.
%K sesquiterpenoids
%K chondrosterins
%K cytotoxic activity
%U http://www.mdpi.com/1660-3397/12/1/167