%0 Journal Article
%T Solomonsterol A, a Marine Pregnane-X-Receptor Agonist, Attenuates Inflammation and Immune Dysfunction in a Mouse Model of Arthritis
%A Andrea Mencarelli
%A Claudio D'Amore
%A Barbara Renga
%A Sabrina Cipriani
%A Adriana Carino
%A Valentina Sepe
%A Elisa Perissutti
%A Maria Valeria D'Auria
%A Angela Zampella
%A Eleonora Distrutti
%A Stefano Fiorucci
%J Marine Drugs
%D 2014
%I MDPI AG
%R 10.3390/md12010036
%X In the present study we provide evidence that solomonsterol A, a selective pregnane X receptor (PXR) agonist isolated from the marine sponge Theonella swinhoei, exerts anti-inflammatory activity and attenuates systemic inflammation and immune dysfunction in a mouse model of rheumatoid arthritis. Solomonsterol A was effective in protecting against the development of arthritis induced by injecting transgenic mice harboring a humanized PXR, with anti-collagen antibodies (CAIA) with beneficial effects on joint histopathology and local inflammatory response reducing the expression of inflammatory markers (TNF¦Á, IFN¦Ã and IL-17 and chemokines MIP1¦Á and RANTES) in draining lymph nodes. Solomonsterol A rescued mice from systemic inflammation were assessed by measuring arthritis score, CRP and cytokines in the blood. In summary, the present study provides a molecular basis for the regulation of systemic local and systemic immunity by PXR agonists.
%K marine sponge
%K Theonella swinhoei
%K rheumatoid arthritis
%K inflammation
%K pregnane X receptor (PXR)
%K solomonsterol A
%U http://www.mdpi.com/1660-3397/12/1/36