%0 Journal Article
%T Separacenes A每D, Novel Polyene Polyols from the Marine Actinomycete, Streptomyces sp.
%A Munhyung Bae
%A Heegyu Kim
%A Yoonho Shin
%A Byung Yong Kim
%A Sang Kook Lee
%A Ki-Bong Oh
%A Jongheon Shin
%A Dong-Chan Oh
%J Marine Drugs
%D 2013
%I MDPI AG
%R 10.3390/md11082882
%X Separacenes A每D ( 1每 4), novel polyene polyols, were isolated from Streptomyces sp. collected from the southern area of Jeju Island, Korea. The chemical structures of 1每 4 were established by NMR, mass, UV, and IR spectroscopy as well as the modified Mosher＊s method. Separacenes A每B ( 1每 2), which share an identical planar structure but possess different relative configurations, bear tetraene units flanked by two diol moieties, whereas the stereoisomeric separacenes C每D ( 3每 4) possess a triene moiety between two diol substructures. Separacenes A每D each contain a terminal olefinic methylene. Separacene A displayed inhibitory activity against Candida albicans isocitrate lyase and weak cytotoxicity against both the colon carcinoma cell line HCT-116 and the lung cancer cell line A549.
%K marine actinomycete
%K polyene polyol
%K cytotoxicity
%K isocitrate lyase
%U http://www.mdpi.com/1660-3397/11/8/2882