%0 Journal Article
%T Apo-9¡ä-Fucoxanthinone, Isolated from Sargassum muticum, Inhibits CpG-Induced Inflammatory Response by Attenuating the Mitogen-Activated Protein Kinase Pathway
%A Doobyeong Chae
%A Zahid Manzoor
%A Sung Chun Kim
%A Sohyun Kim
%A Tae-Heon Oh
%A Eun-Sook Yoo
%A Hee-Kyoung Kang
%A Jin-Won Hyun
%A Nam Ho Lee
%A Mi-Hee Ko
%A Young-Sang Koh
%J Marine Drugs
%D 2013
%I MDPI AG
%R 10.3390/md11093272
%X Sargassum muticum ( S. muticum) is a brown edible alga and widely distributed in Korea. This report was designed to evaluate the anti-inflammatory properties of apo-9¡ä-fucoxanthinone (APO-9¡ä) isolated from S. muticum on pro-inflammatory cytokine production . S. muticum extract (SME) exhibited significant inhibitory effects on pro-inflammatory cytokine production in bone marrow-derived macrophages (BMDMs) and dendritic cells (BMDCs). APO-9¡ä pre-treatment in the CpG DNA-stimulated BMDMs and BMDCs showed a strong dose-dependent inhibitory effect on interleukin (IL)-12 p40, IL-6 and tumor necrosis factor (TNF)-¦Á production with IC 50 values ranging from 5.31 to 13.79. It exhibited a strong inhibitory effect on the phosphorylation of ERK1/2 and on activator protein (AP)-1 reporter activity. APO-9¡ä pre-treatment exhibited significant inhibition of CpG DNA-induced production of inducible nitric oxide synthase. Taken together, these data suggest that SME and APO-9¡ä have a significant anti-inflammatory property and warrant further studies concerning the potentials of SME and APO-9¡ä for medicinal use.
%K Sargassum muticum
%K apo-9¡ä-fucoxanthinone
%K activator protein-1
%K pro-inflammatory cytokine
%K ERK1/2
%K inflammation
%U http://www.mdpi.com/1660-3397/11/9/3272