%0 Journal Article
%T Enhanced Anti-Obesity Activities of Red Mold Dioscorea When Fermented Using Deep Ocean Water as the Culture Water
%A Li-Chun Wang
%A Tzu-Ying Lung
%A Yi-Hsin Kung
%A Jyh-Jye Wang
%A Tsung-Yu Tsai
%A Bai-Luh Wei
%A Tzu-Ming Pan
%A Chun-Lin Lee
%J Marine Drugs
%D 2013
%I MDPI AG
%R 10.3390/md11103902
%X Deep ocean water (DOW) has, in previous studies, been found to be a novel anti-obesity drink and useful in raising Monascus-produced monascin and ankaflavin levels. This may resolve the limited anti-obesity ability of red mold dioscorea (RMD) known as the Monascus purpureus-fermented Disocorea batatas. This study aims to compare the anti-obesity effect of DOW-cultured RMD (DOW-RMD) and ultra-pure water-cultured RMD (UPW-RMD) in rats fed on a high fat diet. Moreover, the effect of ions composition of DOW and DOW-influenced functional metabolites change of RMD on the differentiation and lipogenesis regulation were investigated using 3T3-L1 pre-adipocytes. In the animal test, compared to UPW-RMD, DOW-RMD possessed better ability to inhibit increases in weight gain, and better feed efficiency, body-fat pad and cross-sectional area of adipocytes. In the cell test, the anti-obesity abilities of DOW-RMD in inhibiting PPAR¦Ã and C/EBP¦Á expression in differentiation and lipoprotein lipase activity in lipogenesis were contributed to by the DOW-increased monascin and ankaflavin levels and the ions of DOW, respectively.
%K deep ocean water
%K obesity
%K Monascus
%K monascin
%K ankaflavin
%U http://www.mdpi.com/1660-3397/11/10/3902