%0 Journal Article
%T New Spirotetronate Antibiotics, Lobophorins H and I, from a South China Sea-Derived Streptomyces sp. 12A35
%A Hua-Qi Pan
%A Song-Ya Zhang
%A Nan Wang
%A Zhan-Lin Li
%A Hui-Ming Hua
%A Jiang-Chun Hu
%A Shu-Jin Wang
%J Marine Drugs
%D 2013
%I MDPI AG
%R 10.3390/md11103891
%X Strain 12A35 was isolated from a deep-sea sediment collected from the South China Sea and showed promising antibacterial activities. It was identified as Streptomyces sp. by the 16S rDNA sequence analysis. Bioassay-guided fractionation using HP20 adsorption, flash chromatography over silica gel and octadecylsilyl (ODS) and semi-preparative HPLC, led to the isolation and purification of five metabolites from the fermentation culture of 12A35. Two new spirotetronate antibiotics, lobophorins H ( 1) and I ( 2), along with three known analogues, O-¦Â-kijanosyl-(1¡ú17)-kijanolide ( 3), lobophorins B ( 4) and F ( 5) were characterized by 1D, 2D-NMR and MS data. These compounds exhibited significant inhibitory activities against Bacillus subtilis. Compounds 1 and 5 exhibited moderate activities against Staphylococcus aureus. In particular, the new compound lobophorin H ( 1) showed similar antibacterial activities against B . subtilis CMCC63501 to ampicillin.
%K lobophorins
%K spirotetronate antibiotics
%K antimicrobial
%K Streptomyces
%K South China Sea-derived actinomycete
%U http://www.mdpi.com/1660-3397/11/10/3891