%0 Journal Article
%T Photobactericides¡ªA Local Option against Multi-Drug Resistant Bacteria
%A Mark Wainwright
%A Leonard Amaral
%J Antibiotics
%D 2013
%I MDPI AG
%R 10.3390/antibiotics2020182
%X The use of light-activated bactericidal agents¡ªphotobactericides¡ªis suggested in local infection in order to conserve conventional antibacterials for more systemic disease. Local administration of a photobactericide such as methylene blue coupled with locally-targeted red light illumination ensures the production of non-specific reactive oxygen species and thus a rapid and localised antibacterial response, regardless of the conventional resistance status. To this end, the response of photobactericides to conventional resistance mechanisms, and their potential use in infection, is discussed.
%K photobactericide
%K conventional resistance mechanisms
%K methylene blue
%U http://www.mdpi.com/2079-6382/2/2/182