%0 Journal Article
%T Phyllodes Tumor of Breast: A Review Article
%A Shashi Prakash Mishra
%A Satyendra Kumar Tiwary
%A Manjaree Mishra
%A Ajay Kumar Khanna
%J ISRN Surgery
%D 2013
%R 10.1155/2013/361469
%X Introduction. Phyllodes tumours are rare fibroepithelial lesions. Accurate preoperative pathological diagnosis allows correct surgical planning and avoidance of reoperation. Treatment can be either wide local excision or mastectomy to achieve histologically clear margins. Discussion. The exact aetiology of phyllodes tumour and its relationship with fibroadenoma are unclear. Women aged between 35 and 55 years are commonly involved. The median tumour size is 4£¿cm but can grow even larger having dilated veins and a blue discoloration over skin. Palpable axillary lymphadenopathy can be identified in up to 10¨C15% of patients but <1% had pathological positive nodes. Mammography and ultrasonography are main imaging modalities. Cytologically the presence of both epithelial and stromal elements supports the diagnosis. The value of FNAC in diagnosis of phyllodes tumour remains controversial, but core needle biopsy has high sensitivity and negative predictive value. Surgical management is the mainstay and local recurrence in phyllodes tumours has been associated with inadequate local excision. The role of adjuvant radiotherapy and chemotherapy remains uncertain and use of hormonal therapy has not been fully investigated. Conclusion. The preoperative diagnosis and proper management are crucial in phyllodes tumours because of their tendency to recur and malignant potential in some of these tumours. 1. Introduction Phyllodes tumors are rare fibroepithelial lesions. They make up 0.3 to 0.5% of female breast tumors [1] and have an incidence of about 2.1 per million, the peak of which occurs in women aged 45 to 49 years [2, 3]. The tumor is rarely found in adolescents and the elderly. They have been described as early as 1774, as a giant type of fibroadenoma [4]. Chelius [5] in 1827 first described this tumor. Johannes Muller (1838) was the first person to use the term cystosarcoma phyllodes. It was believed to be benign until 1943, when Cooper and Ackerman reported on the malignant biological potential of this tumor. In 1981 [6] the World Health Organization adopted the term phyllodes tumor and as described by Rosen [7] subclassified them histologically as benign, borderline, or malignant according to the features such as tumor margins, stromal overgrowth, tumor necrosis, cellular atypia, and number of mitosis per high power field. The majority of phyllodes tumors have been described as benign (35% to 64%), with the remainder divided between the borderline and malignant subtypes. The term phyllodes tumor represents a broad range of fibroepithelial diseases and presence
%U http://www.hindawi.com/journals/isrn.surgery/2013/361469/