%0 Journal Article
%T Clot Lysis and Antimitotic Study of Ficus glomerata Roxb Fruit Extracts
%A Kirankumar Shivasharanappa
%A Ramesh Londonkar
%J ISRN Pharmacology
%D 2014
%R 10.1155/2014/975303
%X The present study was carried out to investigate the thrombolytic and antimitotic potentiality of various extracts of fruits of Ficus glomerata, a traditional medicinal plant, using an in vitro assay method. Three crude extracts such as petroleum ether (FGPE), chloroform (FGCE), and methanol (FGME) were used for the study, with a standard (streptokinase) and negative control (sterile distilled water) to validate the method. The thrombolytic nature of the plant was found significant with methanol extract and chloroform and petroleum ether extracts have recorded mild activity, when compared with the negative control (sterile distilled water). The extracts have shown mild clot lysis, that is, 2.16%, 23.06%, 27.60%, and 47.74% of sterile distilled water, FGPE, FGCE, and FGME, respectively, while the standard (streptokinase) has shown 74.22% clot lysis. FGME inhibited the root growth in number as well as length effectively, followed by FGPE, while FGCE exhibited moderate antimitotic activity and it was supported by mitotic index. Therefore, the obtained results suggest that among all the extracts of plant the methanolic extract has shown highest thrombolytic and antimitotic activity. 1. Introduction Ficus glomerata Roxb (Moraceae) is widely used in folk medicine for the treatment of various diseases [1]. The fig tree possesses antibacterial, antifungal, antiseptic, and analgesic qualities [2¨C5]. Thus, the present study is aimed at screening of different extracts of Ficus glomerata fruit for its clot lysis (thrombolytic activity) and antimitotic activity by using an in vitro assay method. These pharmacological activities have been selected because of their great medicinal relevance. In recent years, it is observed that the heart diseases are increasing to a great extent and side effects of synthetic drugs are becoming an ever-increasing therapeutic problem. Hence, it is needed to find out the safe, less or no side effective herbal drugs, because natural products of higher plants may give a new source of thrombolytic agents, as well as antimitotic agents [6]. A blood clot (thrombus) develops in the circulatory system due to failure of homeostasis which causes vascular blockage and while recovering leads to serious consequences in thrombotic diseases such as myocardial or cerebral problems, at times leading to death [7]. Thrombolytic agents that include tissue plasminogen activator (t-PA), urokinase (UK), and streptokinase (SK) are used across the world for the treatment of these diseases. In India, though streptokinase and urokinase are widely used due to
%U http://www.hindawi.com/journals/isrn.pharmacology/2014/975303/