%0 Journal Article
%T Development and Evaluation of Sustained Release Tablet of Betahistine Hydrochloride Using Ion Exchange Resin Tulsion T344
%A Vijay D. Wagh
%A Nilesh Pawar
%J ISRN Pharmaceutics
%D 2012
%R 10.5402/2012/438342
%X An attempt was made to sustain the release of Betahistine hydrochloride by complexation technique using strong cation-exchange resin, Tulsion T344. The drug loading onto ion-exchange resin was optimized for mixing time, activation, effect of pH, swelling time, ratio of drug£¿:£¿resin, and temperature. The resinate was evaluated for micromeritic properties and characterized using XRPD and IR. For resinate sustained release tablets were formulated using hydoxypropyl methylcellulose K100M. The tablets were evaluated for hardness, thickness, friability, drug content, weight variation, and in vitro drug release. Tablets thus formulated (Batch T-3) provided sustained release of drug over a period of 12£¿h. The release of Betahistine HCl from resinate controls the diffusion of drug molecules through the polymeric material into aqueous medium. Results showed that Betahistine HCl was formulated into a sustained dosage form as an alternative to the conventional tablet. 1. Introduction Betahistine hydrochloride is an orally administered antihistaminic drug. The chemical name of Betahistine is N-methyl-2-(pyridin-2-yl)-ethanamine. Betahistine has a very strong affinity for histamine H3 receptors and a weak affinity for histamine H1 receptors. It has been used to control vertigo in patients of Meniere¡¯s disease; it possibly acts by causing vasodilation in the internal ear. However short biological half-life of Betahistine HCl (2-3£¿h) necessitates frequent (four times a day) administration of the drug [1¨C3]. Ion exchange resins have versatile properties as drug delivery vehicles and have been extensively studied in the development of novel drug delivery systems. Cation exchange resins containing strong sulfonic acid group form a strong bond with cationic drugs, and elution of drug from resinate is slower [4]. Ion exchange resins are cross-linked, water insoluble, polymer-carrying, ionizable functional groups. Drugs can be loaded onto the resins by an exchanging reaction, and, hence, a drug-resin complex (drug resinate) is formed [5]. Ion exchange can be defined as a reversible process in which ions of like sign are exchanged between liquid and solid, a highly insoluble body in contact with it [6]. The drug is released from the resinates by exchanging with ions in the gastrointestinal fluid, followed by drug diffusion. Being high molecular weight water insoluble polymers, the resins are not absorbed by the body and are therefore inert [7]. The present research was directed towards the development of sustained release dosage form of Betahistine HCl using ion exchange
%U http://www.hindawi.com/journals/isrn.pharmaceutics/2012/438342/